Yesterday, many girls came to me and asked me: Do I still need to lose weight? What is the effect of this medicine? Most importantly, where can I buy it? Are you lying to me?
I can only responsibly tell you:
Alright, let me take my time answering your questions.
1、 Do I still need to lose weight?
This... Can you send me a photo first to see....
There's no point in not losing weight. I'll teach you how to decide whether to lose weight or not.
Body Mass Index (BMI), also known as Body Mass Index, is a commonly used international standard to measure the degree of obesity and health of the human body.
BMI=Weight (kg)/[Height (m)] 2
For example, a person with a height of 1.75 meters and a weight of 68 kilograms has a BMI of 68/1.752=22.2 (kg/m2). The normal BMI of Chinese people defined by the National Health and Family Planning Commission is 18.5-23.9kg/m2.
Now, quickly calculate your BMI. If your BMI has changed too much from before, I can only say:
If your BMI is below 18.5kg/m2, I advise you to be a quiet girl and stop messing around. The lower the weight, the better. Low weight, overweight, and obesity all have an increased risk of death. A study published in the Lancet in July 2016 showed that individuals with a BMI between 20-25kg/m2 had the lowest risk of all cause death. What, you don't believe it? Then pay close attention to the WeChat official account of the Medical Club and see the research results in a few days.
2、 What is the basis for losing weight with Liraglutide?
Lilalutide has been used to treat type 2 diabetes in the United States since 2010. After several large-scale phase III clinical trials confirmed the effectiveness and safety of 3.0 mg/day of liraglutide in the treatment of obesity, the US FDA approved liraglutide (trade name Saxenda) for the treatment of obesity at the end of 2014. BMI ≥ 30 kg/m2 or BMI ≥ 27 kg/m2 with at least one weight related complication (such as hypertension, diabetes or dyslipidemia) can be used for long-term weight management on the basis of adhering to lifestyle intervention. This is the fifth weight-loss drug approved for market application in the United States after orlistat, chlorkaserin, phentermine/topiramate and bupropion/naltrexone.
Different from the dosage of 1.2 mg or 1.8 mg for type 2 diabetes, the dosage of this drug for obesity is 3.0 mg. It should be noted that lilalutide cannot be used in combination with other human glucagon like peptide (GLP) analogues. In addition, if the patient loses less than 4% of their weight compared to baseline after 16 weeks of use, the medication needs to be discontinued.
While approving the treatment of obesity with liraglutide, Novo Nordisk carried out the LEADER study to evaluate the impact of liraglutide 1.8 mg on cardiovascular outcomes, cancer and other adverse events. Research has found that liraglutide can reduce the incidence of cardiovascular events and all-cause mortality, without increasing the incidence of benign or malignant tumors [3]. (For LEADER research, you can return to the homepage of the Medical Association and reply with "LEADER" to view it)
3、 So, where can I buy it?
This question is very good. Currently, liraglutide injection, which is used to treat obesity, has not been launched in China. The 2016 version of diabetes prevention and treatment guidelines issued by the American diabetes Association has recommended that Lilalutide injection can be used to lose weight [4]. Compared to placebo, using liraglutide injection for one year can reduce an average weight of 5.8kg, and the treatment cost is approximately 15000 US dollars (US dollars! US dollars! Is US dollars!). According to the exchange rate on September 13, 2016, a one-year treatment with a weight loss of 5.8kg would require approximately 100000 RMB.
I'm scared to death of the baby. By this calculation, one kilogram of meat on my body is worth 17200 yuan! Hurry up and have a bottle of beer with 10 skewers to crush the weight. I won't dare to lose weight casually anymore...
Having said so much, can we buy it domestically? This is really not good. The indication of Lilalutide injection listed in China is 1.8mg/day to treat type 2 diabetes. However, the ingredients of drugs for diabetes and weight loss are the same, but the dosage is different. The 18mg injection listed in China costs approximately 900 yuan per injection, and if used at a rate of 3mg per angel, it costs approximately 4500 yuan per month and 54000 yuan per year.
However, as a wise reminder, you must consult a doctor at the hospital and never purchase or use it without permission. Because when Lilalutide is used to treat diabetes, the dose also needs to be adjusted. The following is the instructions for the treatment of type 2 diabetes with liraglutide:
The initial dose of liraglutide is 0.6mg per day. After at least one week, the dosage should be increased to 1.2mg. It is expected that some patients will benefit from increasing the dosage from 1.2mg to 1.8mg. Based on clinical response, in order to further improve the hypoglycemic effect, the dosage can be increased to 1.8mg after at least one week. The recommended daily dose does not exceed 1.8mg.
In addition, liraglutide, which is used for weight loss, may also cause gastrointestinal adverse reactions such as nausea, vomiting, diarrhea, and abdominal pain after use.
4、 Conclusion
Having said so much, do you understand the most important point? That is to pay close attention to the WeChat official account of the Medical Club, learn more interesting research, and move up together
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